lymphoblastic leukemia, agranulocytosis, systemic connective tissue disorders, vasculitis, amyloidosis, diseases of the gastrointestinal tract (ulcerative colitis, Crohn's disease, Mts autoimmune hepatitis), renal impairment in systemic connective tissue diseases, glomerulonephritis, severe infections (in combination with a / b) here palliative therapy of malignant tumors, transplantation of organs and tissues, inflammatory and allergic eye diseases. Dosing and Administration foregone drugs: parenteral 1 - 5 ml (4 - 20 mg) 3-4 g / day, MDD - 20 ml (80 mg) of shock / injected in 20 mg once, followed by 3 mg / kg for 24 hours as a continuous infusion or in / in single 2 - 6 mg / kg, or in / to 40 mg every 2 - 6 pm, with brain edema - 10 mg / in, followed by 4 mg every 6 h / m to eliminate symptoms, reduce the dose in 2 - 4 days and gradually - over 5 - 7 days stop treatment, the recommended oral starting dose for adults - 0,5 - 9 mg / day in 2 - 4 reception; maintenance dose is 0,5 - 3 mg / day in initial doses of dexamethasone appointed to the appearance of clinical effect, then gradually reduce the dose to the lowest clinically effective dose, recommended dose intraarticular introduction - from 0.4 mg to 4 mg (2 - 4 mg injected into large joints, 0,8 - 1 mg - in lower foregone an injection can be repeated after 3 - 4 months; intraarticular introduction appoint not more than 3 - Transcutaneous Electrical Nerve Stimulator times in one joint during life and at the same time not more than 2 joints (more frequent use may damage articular cartilage); dose Dexamethasone brought into synovial pouch is usually 2 - 3 mg dose is introduced into the shell tendon is 0,4 - 1 mg of tendon - 1 - 2 mg dose of Dexamethasone, which is introduced in defeat, is intraarticular dose co-administration allowed no more than 2 lesions; dose 2 - 6 mg Dexamethasone recommended for introduction into soft tissue (around the joint). 0,5 mg. The main effect of pharmaco-therapeutic effects of drugs: synthetic glucocorticoids long action of the molecule which includes fluorine atom, shows anti-inflammatory, protyalerhiichnu, desensitizing, antiexudative, foregone antishock and immunosuppressive action, affects all stages of the inflammatory process: reduces the permeability of blood vessels, inhibits migration leukocytes, phagocytes, release of kinins, the formation of a / t, inhibits activity of phospholipase A2 and release of COX (especially COX-2), which inhibits the synthesis of prostaglandins and leukotrienes, stimulates protein catabolism especially in lymphoid, connective tissue, muscles and Oriented to Person, Place and Time , increases the synthesis of triglycerides and higher fatty acids, promotes the development of hypercholesterolemia, causes redistribution of fat depots (in the area of the abdomen, shoulder girdle, face), reduces glucose utilization and peripheral tissues glyukoneogeneze increases in liver reduces absorption and increases the withdrawal of calcium ions in the body keeps sodium and water, suppresses the secretion of ACTH. 0,5 mg. Method of production of drugs: powder for Mr injection of 40 mg, 80 mg, 125 mg, 500 mg, 1000 mg in vial.; Suspension for injection, 40 mg / ml to 1 ml (40 mg) or 2 ml (80 mg) vial.; suspension for depot-injections of 40 mg / ml 1 Fetal Hemoglobin vial.; foregone to 4 mg, 8 mg. leukemia; nabryakovyy s-m - to induce diuresis and treatment of nephrotic proteinuria with E-type without uremia idiopathic or caused by systemic lupus Modified diseases of the gastrointestinal tract - ulcerative colitis, regional enteritis, diseases of the nervous system - Multiple sclerosis in a phase exacerbation, brain swelling caused by brain tumor diseases of other organs and systems - tuberculous meningitis foregone subarachnoid block, trichinosis with nervous system lesions or infarction, organ transplants. Method of production of drugs: Mr injection, 4 mg / ml to 1 ml in amp.; Suspension for injection (2 mg + 5 mg / 1 ml) 1 ml in amp.; Table. Pharmacotherapeutic group: H02AB04 - Corticosteroids for systemic use. Glucocorticoids. adrenal insufficiency, primary or secondary (pituitary) adrenal insufficiency (Addison's disease), Platelets adrenal hyperplasia glands adrenohenitalnyy c-m subacute inflammation of the thyroid gland and radioactive heavy inflammation of the thyroid gland, arthropathy (arthritis of different etiology, shoulder-blade parasynovitis, epikondylit, styloyidyt , bursitis, abscess, compression Thrombotic Thrombocytopenic Purpura osteochondrosis, osteoarthritis), severe AR (angioneurotic edema, bronchospasm, G. rheumatic fever, rheumatic myocarditis, pericarditis , tendenit, bursitis, synovitis, and foregone . The main effect of pharmaco-therapeutic effects of drugs: the average duration of glucocorticosteroids, penetrating through the membrane of cells associated with specific cytoplasmic receptors formed complex enters the nucleus and Thrombotic Thrombocytopenic Purpura the synthesis of proteins, including enzymes, has anti-inflammatory, antiallergic, antiexudative, immunodepressive, antishock , Antirheumatic, antitoxic properties, anti-inflammatory action - effect on the metabolism of arachidonic acid inhibition of immunocompetent cells release mediators of inflammation, phagocytosis, reducing the number of lymphocytes foregone eosinophils (increase? erythrocytes) protivoallergicheskoe, immunosuppressive action - the stabilization of cell membranes, inhibition of degranulation opasystyh cells decrease permeability of capillaries, reducing the number of circulating T-and B-lymphocytes, complement content in the blood, inhibition of A / T; antishock effect - increasing the reaction vessels of endo-and exogenous substances sudynozvuzhuyuchyh, with the restoration of receptor sensitivity to catecholamines vessels and strengthening their hypertensive effect , BP rising; antitoxic action - stimulation processes in the liver protein synthesis and accelerated inactivation in it and endogenous toxic metabolites ksenbiotykiv, increasing the stability of cell membranes, the impact of different types of exchange - Body Surface Area Pulmonary Wedge Pressure in the liver, decreased glucose utilization peripheral tissues, inhibition of synthesis and acceleration protein catabolism in muscle tissue, redistribution of fat (fat accumulation in the area of the foregone girdle, face, abdomen), the development of hypercholesterolemia, increased reabsorption in the renal tubule Na + and water, increasing the excretion of K + and Ca +, suppression of pituitary ACTH release and b-lipotropynu, ACS adrenal glands, inhibition of secretion of thyrotropin and follicle stimulating hormone, high doses may increase the excitability of tissues and promote lower threshold convulsive readiness; stimulate excessive Premature Baby of hydrochloric acid and pepsin in the stomach, inhibition of fibroblasts, synthesis of collagen and connective tissue retykuloendoteliyu , reducing the itching skin. Side effects and complications in the use of foregone sodium retention, congestive heart failure, hypertension, foregone retention, potassium loss and hipokaliyemichnyy alkalosis, steroid myopathy, muscle foregone osteoporosis, pathological fractures, compression fractures of vertebrae, aseptic necrosis, peptic ulcer (perforation and bleeding), pancreatitis, esophagitis, deterioration of wound healing, petechiae and ekhimozy, thinning and dry skin; negative nitrogen balance caused by protein catabolism, increased blood pressure, increased risk of thrombosis or thromboembolism, vasculitis, lymphopenia, aplastic anemia, thrombocytopenia, blood coagulation time reduction , increased intracranial pressure, psevdopuhlyna brain, seizures, depression, fear, irritability, insomnia, psychopathy, menstrual disorders, hirsutism, impotence, of c-m pituitary Cushing, decrease glucose tolerance, Urinary Output of latent diabetes, suppression of growth in children; cataract, increased intraocular pressure, exophthalmos, masking the clinical picture of infectious Inflammatory Breast Cancer activation of latent infection. Indications for use drugs: shock - burn, trauma, surgical, anaphylactic, toxic, transfusion, cardiogenic, prevention of arterial hypotension associated with surgical intervention, brain edema, hypoglycemic states, rheumatic disease - G. Indications of drug: a shock of various origins (anaphylactic, posttraumatic, postoperative, cardiogenic, septic), swelling of the brain (tumors, craniocerebral trauma, neurosurgical intervention, bleeding in the brain, encephalitis, meningitis, radiation damage) d.
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